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KMID : 1007520150240010347
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Food Science and Biotechnology
2015 Volume.24 No. 1 p.347 ~ p.351
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Sulforaphane Inhibited Tumor Necrosis Factor-α Induced Migration and Invasion in Estrogen Receptor Negative Human Breast Cancer Cells
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Bao Cheng
Ko Ji-won
Park Hyun-Chang
Kim Min-Chae
Kim Jong-kee
Auh Joong-Hyuck
Lee Hong-Jin
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Abstract
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Sulforaphane significantly (p<0.05) inhibited tumor necrosis factor (TNF)-α induced cellular migration and invasion in MCF10DCIS.com human breast cancer cells, compared with controls. mRNA and protein expressions of MMPs, including MMP-2, MMP-9, and MMP-13, and the enzymatic activities of MMP-2 and MMP-9 were suppressed by sulforaphane treatments at 1, 5, and 10 μM concentration in MCF10DCIS.com cells. Sulforaphane should be considered as a potent agent for retardation of mammary tumorigenesis.
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KEYWORD
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breast cancer, invasion, matrix metalloproteinase, migration, sulforaphane
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